When treated with Anti-Retroviral Therapy HIV-infected children slowly recover their naive and memory CD4 and CD8 T cells. We will be modeling the large amount of clinical data collected within the international EPIICAL consortium to estimate these recovery rates, to classify patients into clusters, and to identify criteria for treatment options (such as treatment interruption testing for functional cure). The modeling involves fitting ODE models to the data and statistical analysis of the estimated parameters and the original data. The work will be performed in close collaboration with the clinicians and statisticians of the EPIICAL consortium and with Dr. Andrew Yates in Glasgow. A typical recent paper is Payne et al. Lancet (2015): http://dx.doi.org/10.1016/S1473-3099(15)00087-0.
We are looking for a PhD student with a keen interest in combining mathematical modeling with immunology. Experience with mathematical modeling is required. Please contact Prof.dr. Rob J. de Boer for information (http://tbb.bio.uu.nl/rdb).