Immunobiology Course

CD8 T cell killing its target.Wiedemann A et al. PNAS 2006;103:10985-10990

The immunobiology course starts on tuesday 23 April 2019. The course book is Parham's The Immune System (4th edition).


The immune system comprises innate and acquired defense mechanisms against (pathogenic) microorganisms. Immunology has traditionally been a qualitative science describing the cellular and molecular components of the immune system and their functions. In the last twenty years this traditional approach is being replaced by a systems biology approach, where theoretical studies helps to interpret experimental data, to resolve controversies, and --most importantly-- to suggest novel experiments allowing for more conclusive and more quantitative interpretations. This course is planned to give an overview of wet and theoretical immunological research. We aim to:

  • provide insight into the function of the immune system in health and disease
  • give an introduction to the use of mathematical models and bioinformatics in immunological research.


Active participation in the computer assignments required. Please keep a lab-book during the computer exercises (choose a format you are comfortable with, google documents, word, power point). To be able to pass this course you need to submit the lab-book on the day of the exam. If you did all the computer exercises together in a group, then you can submit one labjournal for your group. Please indicate all names. The deadline for delivering the lab-book is the same day as the final exam.

The final grade of the course is calculated as:

  • the exams (60%)
  • one written assignment computer exercises (25%)
  • presentation of the articles and article discussions (15%).

The sssignment will be about an exercise of your choice concerning the mathematical modeling or bioinformatics (25%). You can choose one of the six computer exercises. You are supposed to submit one report per group. If you are working on your own, you can also submit an individual report.

The report can be either in dutch or in english, and it should contain a contribution statement describing who did what.


The exams are a combination of open questions and multiple choice questions. Your exam grade should be minimum 5,5 to be able to pass this course.